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The main goal of this essay is to argue that in a multicultural and globalised world, the indigenisation of knowledge production has to be pursued in a way that demonstrates an element of inclusivity. To achieve this goal this article’s structure has three foci. Firstly, it is argued that the indigenisation of knowledge must be pursued under the presumption of a recognition that all knowledge is cultural or context specific to some degree. As such, the multicultural nature and plurality of knowledge systems formations should be acknowledged, as well as the fact that all knowledge production includes an aspect of the indigenisation of knowledge. Secondly, against this broader background, the argument for the indigenisation of knowledge in Africa goes hand-in-hand with the promotion of the intellectualisation of knowledge that is often regarded by Western scholarship as ‘primitive’, and thus redundant, in the face of modernity. This, however, is not only a universal for the production of all knowledge(s), but also foundational to all knowledge development, and should be recognised as such. Finally, given the plurality of knowledge formations, and the African celebration and development of its own knowledge formations, the quest for the indigenisation and intellectualisation of knowledge in African context, should be seen as a quest for the inclusionary appreciation of a multiplicity of global knowledges, whereby all knowledge is understood as context specific to some degree, and contributing to both local and general human wellbeing. This latter perspective implies a deliberately ethical stance, to the effect that in a globalised and multicultural world, no knowledge system should be privileged as superior to any other knowledge system, and none, regarded as inferior.