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Any performance management (PM) practice implemented by an organisation has a direct impact on organisational performance and development; this paper therefore discusses challenges based on primary and secondary research findings, with the aim to explore how these findings correlate with how the successful implementation of PM practices is perceived and applied in the Ministry of Health and Child Care (MOHCC) in Zimbabwe. A qualitative research approach was used to collect data. The findings confirm that the implementation of PM has been marred by various challenges, which have, in turn, greatly affected performance results. Challenges identified by this study were, and continue to be, experienced at different levels of PM implementation strategies (e.g., at the formulation stage versus the implementation stage), and hence may hinder the effective implementation of PM practices in the MOHCC. The paper offers recommendations for consideration at political, policy, organisational, departmental, individual, and stakeholder levels.